Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution.
Identifieur interne : 000234 ( Main/Exploration ); précédent : 000233; suivant : 000235Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution.
Auteurs : Jian Hu [République populaire de Chine] ; Sandesh Shrestha [États-Unis] ; Yuxin Zhou [République populaire de Chine] ; Joann Mudge [États-Unis] ; Xili Liu [République populaire de Chine] ; Kurt Lamour [États-Unis]Source :
- PloS one [ 1932-6203 ] ; 2020.
Descripteurs français
- KwdFr :
- Allèles (MeSH), Analyse de séquence d'ADN (MeSH), Analyse sur cellule unique (MeSH), Aneuploïdie (MeSH), Cartographie chromosomique (MeSH), Cucumis sativus (microbiologie), Génotype (MeSH), Légumes (microbiologie), Maladies des plantes (microbiologie), Perte d'hétérozygotie (MeSH), Phytophthora (isolement et purification), Phytophthora (physiologie), Polymorphisme de nucléotide simple (MeSH), Reproduction asexuée (génétique), Spores (génétique), Variation génétique (MeSH), Évolution biologique (MeSH).
- MESH :
- génétique : Reproduction asexuée, Spores.
- isolement et purification : Phytophthora.
- microbiologie : Cucumis sativus, Légumes, Maladies des plantes.
- physiologie : Phytophthora.
- Allèles, Analyse de séquence d'ADN, Analyse sur cellule unique, Aneuploïdie, Cartographie chromosomique, Génotype, Perte d'hétérozygotie, Polymorphisme de nucléotide simple, Variation génétique, Évolution biologique.
English descriptors
- KwdEn :
- Alleles (MeSH), Aneuploidy (MeSH), Biological Evolution (MeSH), Chromosome Mapping (MeSH), Cucumis sativus (microbiology), Genetic Variation (MeSH), Genotype (MeSH), Loss of Heterozygosity (MeSH), Phytophthora (isolation & purification), Phytophthora (physiology), Plant Diseases (microbiology), Polymorphism, Single Nucleotide (MeSH), Reproduction, Asexual (genetics), Sequence Analysis, DNA (MeSH), Single-Cell Analysis (MeSH), Spores (genetics), Vegetables (microbiology).
- MESH :
- genetics : Reproduction, Asexual, Spores.
- isolation & purification : Phytophthora.
- microbiology : Cucumis sativus, Plant Diseases, Vegetables.
- physiology : Phytophthora.
- Alleles, Aneuploidy, Biological Evolution, Chromosome Mapping, Genetic Variation, Genotype, Loss of Heterozygosity, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Single-Cell Analysis.
Abstract
Oomycete plant pathogens are difficult to control and routine genetic research is challenging. A major problem is instability of isolates. Here we characterize >600 field and single zoospore isolates of Phytophthora capsici for inheritance of mating type, sensitivity to mefenoxam, chromosome copy number and heterozygous allele frequencies. The A2 mating type was highly unstable with 26% of 241 A2 isolates remaining A2. The A1 mating type was stable. Isolates intermediately resistant to mefenoxam produced fully resistant single-spore progeny. Sensitive isolates remained fully sensitive. Genome re-sequencing of single zoospore isolates revealed extreme aneuploidy; a phenomenon dubbed Dynamic Extreme Aneuploidy (DEA). DEA is characterized by the asexual inheritance of diverse intra-genomic combinations of chromosomal ploidy ranging from 2N to 3N and heterozygous allele frequencies that do not strictly correspond to ploidy. Isolates sectoring on agar media showed dramatically altered heterozygous allele frequencies. DEA can explain the rapid increase of advantageous alleles (e.g. drug resistance), mating type switches and copy neutral loss of heterozygosity (LOH). Although the mechanisms driving DEA are unknown, it can play an important role in adaptation and evolution and seriously hinders all aspects of P. capsici research.
DOI: 10.1371/journal.pone.0227250
PubMed: 31910244
PubMed Central: PMC6946123
Affiliations:
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A major problem is instability of isolates. Here we characterize >600 field and single zoospore isolates of Phytophthora capsici for inheritance of mating type, sensitivity to mefenoxam, chromosome copy number and heterozygous allele frequencies. The A2 mating type was highly unstable with 26% of 241 A2 isolates remaining A2. The A1 mating type was stable. Isolates intermediately resistant to mefenoxam produced fully resistant single-spore progeny. Sensitive isolates remained fully sensitive. Genome re-sequencing of single zoospore isolates revealed extreme aneuploidy; a phenomenon dubbed Dynamic Extreme Aneuploidy (DEA). DEA is characterized by the asexual inheritance of diverse intra-genomic combinations of chromosomal ploidy ranging from 2N to 3N and heterozygous allele frequencies that do not strictly correspond to ploidy. Isolates sectoring on agar media showed dramatically altered heterozygous allele frequencies. DEA can explain the rapid increase of advantageous alleles (e.g. drug resistance), mating type switches and copy neutral loss of heterozygosity (LOH). Although the mechanisms driving DEA are unknown, it can play an important role in adaptation and evolution and seriously hinders all aspects of P. capsici research.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31910244</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>10</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>1</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution.</ArticleTitle><Pagination><MedlinePgn>e0227250</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0227250</ELocationID><Abstract><AbstractText>Oomycete plant pathogens are difficult to control and routine genetic research is challenging. A major problem is instability of isolates. Here we characterize >600 field and single zoospore isolates of Phytophthora capsici for inheritance of mating type, sensitivity to mefenoxam, chromosome copy number and heterozygous allele frequencies. The A2 mating type was highly unstable with 26% of 241 A2 isolates remaining A2. The A1 mating type was stable. Isolates intermediately resistant to mefenoxam produced fully resistant single-spore progeny. Sensitive isolates remained fully sensitive. Genome re-sequencing of single zoospore isolates revealed extreme aneuploidy; a phenomenon dubbed Dynamic Extreme Aneuploidy (DEA). DEA is characterized by the asexual inheritance of diverse intra-genomic combinations of chromosomal ploidy ranging from 2N to 3N and heterozygous allele frequencies that do not strictly correspond to ploidy. Isolates sectoring on agar media showed dramatically altered heterozygous allele frequencies. DEA can explain the rapid increase of advantageous alleles (e.g. drug resistance), mating type switches and copy neutral loss of heterozygosity (LOH). Although the mechanisms driving DEA are unknown, it can play an important role in adaptation and evolution and seriously hinders all aspects of P. capsici research.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Jian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Agro-grassland Science, Nanjing Agricultural University, Nanjing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shrestha</LastName><ForeName>Sandesh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Kansas State University, Manhattan, Kansas, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Yuxin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Plant Protection, Nanjing Agricultural University, Nanjing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mudge</LastName><ForeName>Joann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Center for Genome Resources, Santa Fe, New Mexico, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xili</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Plant Pathology, China Agricultural University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lamour</LastName><ForeName>Kurt</ForeName><Initials>K</Initials><Identifier Source="ORCID">0000-0001-6407-8825</Identifier><AffiliationInfo><Affiliation>Department of Entomology and Plant Pathology, The University of Tennessee, Knoxville, Tennessee, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000782" MajorTopicYN="Y">Aneuploidy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="N">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002874" MajorTopicYN="N">Chromosome Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018553" MajorTopicYN="N">Cucumis sativus</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019656" MajorTopicYN="N">Loss of Heterozygosity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012100" MajorTopicYN="N">Reproduction, Asexual</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059010" MajorTopicYN="N">Single-Cell Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013170" MajorTopicYN="N">Spores</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014675" MajorTopicYN="N">Vegetables</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading></MeshHeadingList><CoiStatement>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate 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Chine"><noRegion><name sortKey="Hu, Jian" sort="Hu, Jian" uniqKey="Hu J" first="Jian" last="Hu">Jian Hu</name></noRegion><name sortKey="Liu, Xili" sort="Liu, Xili" uniqKey="Liu X" first="Xili" last="Liu">Xili Liu</name><name sortKey="Zhou, Yuxin" sort="Zhou, Yuxin" uniqKey="Zhou Y" first="Yuxin" last="Zhou">Yuxin Zhou</name></country><country name="États-Unis"><region name="Kansas"><name sortKey="Shrestha, Sandesh" sort="Shrestha, Sandesh" uniqKey="Shrestha S" first="Sandesh" last="Shrestha">Sandesh Shrestha</name></region><name sortKey="Lamour, Kurt" sort="Lamour, Kurt" uniqKey="Lamour K" first="Kurt" last="Lamour">Kurt Lamour</name><name sortKey="Mudge, Joann" sort="Mudge, Joann" uniqKey="Mudge J" first="Joann" last="Mudge">Joann Mudge</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution.
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